This is a list of number one singles of 2010 on CBC Radio 3's R3-30 charts.
| Date | Artist | Song | Album |
|---|---|---|---|
| January 8 | We Are Wolves | "Me As Enemy" | Invisible Violence |
| January 15 | Said the Whale | "Black Day in December" | Islands Disappear |
| January 22 | The King Khan & BBQ Show | "Crystal Ball" | Invisible Girl |
| January 29 | John K. Samson | "Heart of the Continent" | City Route 85 |
| February 5 | Owen Pallett | "Lewis Takes Action" | Heartland |
| February 12 | |||
| February 19 | Sloan | "Where Are You Now?" | Hit & Run |
| February 26 | Woodhands | "CP24" | Remorsecapade |
| March 5 | Basia Bulat | "Heart of My Own" | Heart of My Own |
| March 12 | Jason Collett | "Love Is a Dirty Word" | Rat a Tat Tat |
| March 19 | The Besnard Lakes | "Albatross" | The Besnard Lakes Are the Roaring Night |
| March 26 | |||
| April 2 | Brasstronaut | "Slow Knots" | Mt. Chimaera |
| April 9 | Zeus | "I Know" | Say Us |
| April 16 | |||
| April 23 | Kinnie Starr | "A Different Day" | A Different Day |
| April 30 | Plants and Animals | "The Mama Papa" | La La Land |
| May 7 | |||
| May 14 | Caribou | "Odessa" | Swim |
| May 21 | Hannah Georgas | "Bang Bang You're Dead" | This Is Good |
| May 28 | Broken Social Scene | "Forced to Love" | Forgiveness Rock Record |
| June 4 | The New Pornographers | "Your Hands (Together)" | Together |
| June 11 | Holy Fuck | "Latin America" | Latin |
| June 18 | Wintersleep | "Black Camera" | New Inheritors |
| June 25 | Crystal Castles | "Celestica" | Crystal Castles |
| July 2 | Shad | "Yaa I Get It" | TSOL |
| July 9 | |||
| July 16 | Tokyo Police Club | "Wait Up (Boots of Danger)" | Champ |
| July 23 | Hot Hot Heat | "21 @ 12" | Future Breeds |
| July 30 | Stars | "Fixed" | The Five Ghosts |
| August 6 | Sarah Harmer | "Captive" | Oh Little Fire |
| August 13 | Wolf Parade | "Ghost Pressure" | Expo 86 |
| August 20 | The New Pornographers | "Crash Years" | Together |
| August 27 | Broken Social Scene | "Texico Bitches" | Forgiveness Rock Record |
| September 3 | The Arcade Fire | "Ready to Start" | The Suburbs |
| September 10 | |||
| September 17 | |||
| September 24 | |||
| October 1 | Black Mountain | "The Hair Song" | Wilderness Heart |
| October 8 | |||
| October 15 | Tokyo Police Club | "Big Difference" | Champ |
| October 22 | Land of Talk | "Swift Coin" | Cloak and Cipher |
| October 29 | The Meligrove Band | "Bones Attack!!!" | Shimmering Lights |
| November 5 | |||
| November 12 | Quest for Fire | "Set Out Alone" | Lights from Paradise |
| November 19 | Owen Pallett | "A Man with No Ankles" | A Swedish Love Story |
| November 26 | The Russian Futurists | "Hoeing Weeds Sowing Seeds" | The Weight's on the Wheels |
| December 3 | Diamond Rings | "Something Else" | Special Affections |
| December 11 | Suuns | "Arena" | Zeroes QC |
| December 18 | Stars | "Wasted Daylight" | The Five Ghosts |
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